

Elsa signs on the dotted line, then stands up, showing that she is pregnant. Joan offers Elsa a generous settlement for agreeing to take her research to the next stage. This will guarantee the company's existence for years to come. In the final scene, which takes place some time later in the office of Joan Chorot ( Simona Maicanescu), Joan tells Elsa that Dren's body was filled with a variety of unique compounds, including high levels of CD356. A film of great ideas let down by overheating the plot for shock values, while the levity inserted into the play is misguided and damaging for dramatic worth. As Clive dies, Elsa bashes Dren in the head with a rock, then collapses in the snow. Director Vincenzo Natali has shown with Cube and Cypher he has something to offer the horror/sci-fi splinters of film, but this is a mixed bag. He sneaks up behind Elsa and Dren, and runs a stake through Dren's back, but Dren stabs Clive with the poison stinger on the tip of his tail.
DREN SPLICE DNA FULL
Clive regains full consciousness and stumbles towards Elsa, finding his brother Gavin dead in the snow. "In.side.you," Dren replies and rapes her. Suddenly Dren rises from the water, and it is readily apparent that the same thing as happened to Ginger has happened to Dren.she has become a he. Clive manages to break free, and Elsa pulls him from the water. He tries to fish it out, but Dren pulls him into the pond and holds him under the water. Clive tries to run to him but drops the flashlight in a pond. They try to coax her down, but she flies past them and grabs Gavin. They hear another shriek, and they suddenly see a fully mutated Dren standing on the roof.

El director no sólo reconoció que el final parecía establecer una secuela, sino que declaró que siempre le gusta hacer películas «con final abierto«, incluso si no tiene intención de hacer una secuela. Elsa, Clive, and Gavin look around and find him bloodied and murdered, hanging from a tree. En una entrevista de 2010 con Bloody Disgusting, Natali habló sobre el final de Splice. Barlow goes behind the barn to do so, but there is a sudden gust of wind, a shriek, and Barlow is gone. Barlow demands to see Dren, so Elsa tosses him a shovel and tells him to dig her up. Barlow discovered human DNA in the samples and got Gavin to tell him about Dren. As they're burning her things, Gavin ( Brandon McGibbon) and Barlow ( David Hewlett) drive up.

Elsa and Clive return to the barn to find Dren dying.
